Expression of Memory (CD45RO+) and Naive (CD45RA+) T-cells in Newborn Infants with Sepsis. † 1334

CD45RA In Vivo: CD45RACD8 T Cells Comprise Both Naive and Memory Cells

Persistence of naive CD45RA+ regulatory T cells in adult life.

Regulatory T cells (TREGs) constitutively expressing CD4, CD25, and the transcription factor Foxp3 can prevent a wide range of experimental and spontaneous autoimmune diseases in mice. In humans, CD4+CD25bright T cells, predominantly within the CD45RO+ activated/memory subset in adults and the CD45RA+ naive T-cell subset in infants, are considered to be the equivalent subset. Using novel combin...

Human Virus-Specific CD8 CTL Clones Revert from CD45RO high to CD45RA In Vivo: CD45RACD8 T Cells Comprise Both Naive and Memory Cells

Human autoreactive CD4+ T cells from naive CD45RA+ and memory CD45RO+ subsets differ with respect to epitope specificity and functional antigen avidity.

T cells with specificity for self-Ags are normally present in the peripheral blood, and, upon activation, may target tissue Ags and become involved in the pathogenesis of autoimmune processes. In multiple sclerosis, a demyelinating disease of the CNS, it is postulated that inflammatory damage is initiated by CD4+ T cells reactive to myelin Ags. To investigate the potential naive vs memory origi...

Protein kinase C isoform expression in CD45RA+ and CD45RO+ T lymphocytes.

Differences in levels of specific enzymes utilized in intracellular signalling could be a factor in the distinct signalling properties observed in memory and naive T cells. We have studied the expression of both classical and non-classical protein kinase of C (PKC) isoenzymes in CD45RA and CD45RO cells using a combination of Western blot and flow cytometric analysis. These data indicate that CD...